By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)
In 1988 we offered our advisor to Bone Marrow Transplan tation. The reception has been enthusiastic and we now have re ceived a flood of severe reviews, feedback and requests to supply an replace in due time. even though a number of books on marrow transplantation have lately been released, their scope and objective have typically been varied. as a result, we now have made up our minds to arrange a moment version of the advisor. Our goal used to be to keep up a quick, concise textual content which by no means theless could include alterations that experience happened over the last 4 or 5 years. we now have streamlined the outline of pretransplant issues, via condensing sections into one (Treatment making plans and Timing of Transplantation). This additionally facilitated the overview of debatable symptoms for marrow transplantation, for instance in sufferers with acute myelogenous leukemia in first chemotherapy-induced remission. we now have up to date the bankruptcy facing conditioning regimens and feature increased the part on donor choice, particularly in regard to the present point of tissue typing and the id of unrelated volunteer donors. within the bankruptcy on assortment, processing, and infusion of marrow, we've got included fresh advancements, for instance, using closed platforms for marrow harvesting and processing and using strong part separation of stem cells.
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Extra info for A Guide to Bone Marrow Transplantation
Details of previous treatment, including cumulative doses of certain prior (especially cytotoxic) agents, as well as the level of response obtained 3. Specific disease or treatment-related problems 4. Co-morbid medical problems that might complicate or preclude transplantation 5. Allergies, especially to commonly-used medications 6. Transfusions, including number, type, results, reactions 7. Psychologic assessment, with special attention to understanding of the procedure C. Tumor staging studies for malignant diseases 1.
Sanctuary sites 4. Others as required D. Organ toxicity screening 1. Pertinent history (see B2 and B3 above) 2. Renal - Urinalysis - Serum creatinine - Creatinine clearance 3. Hepatic - Liver function studies 4. Pulmonary - Arterial blood gases - Pulmonary function studies - Diffusing capacity of carbon monoxide (DLCO) 5. Cardiac - Left ventricular function evaluation 6. Endocrine Fasting blood sugar - Glucose tolerance test (optimal) - Thyroid function battery - Andrology (for sperm banking) E.
Solid Tumors The place of marrow transplantation in the treatment of solid tumors is not clearly defined. Many solid tumors, such as metastic melanoma, carcinoma of the lung, carcinoma of the breast, recurrent non-seminomatous germ cell tumors are not curable with currently available chemotherapy and offer areas in which to explore the usefulness of marrow transplantation. The major focus of ongoing studies is breast cancer. , more than 10 axillary nodes involved by metastases), have been transplanted with autologous Treatment Planning and Timing of Transplantation 25 marrow.
A Guide to Bone Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Gordon L. Phillips M.D. (auth.)