By M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview
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Extra resources for Acetylcholine. An Approach to the Molecular Mechanism of Action
The basic function of every nerve cell, the axon of which forms a synapse in which the transmission of excitation is chemical, is the release of the mediator. Calcium is essential to this function. Calcium is apparently essential also for the accomplishment of the basic function of many other cells, such as the contraction of muscle cells, the secretion of gland cells and the discharge of hormones by some of the endocrine glands. The mechanism of action of calcium on the performance of the basic function of the cell is not yet properly understood, and may differ in different cells.
2, Same after injection o f D F P (20 /xM/kg). 3 to 6, Same after injection o f various doses o f ambenonium ( A m b ) 5 min before D F P . RGIC SYNAPSE cellular ChE may be inhibited not only by the tertiary, but also by the quaternary inhibitor. e. is situated on the external surface of the axon and its endings, on the external surface of the presynaptic membrane of the synapses. Mclsaak and Koelle (1959) showed that transmission across vegetative ganglia may be facilitated by using not only a tertiary inhibitor, but also by using a quaternary inhibitor that inhibits "external" ChE alone, while leaving the intracellular enzyme fully active.
Other esters of choline may also act as poisons. The following derivatives of acrylylcholine have been identified in the hypobranchial and salivary glands of gastropod molluscs (Whittaker, 1963b): Nr^ C = C-H — C- ~ 0-— CH - —CH 9 R ' = R" == — H ? choline N (XI) (Murexine) Senecioylcholine (X) and especially urocanoylcholine (murexine, XI) possess pronounced curariform actions. The predatory molluscs may make use of these poisons to immobilize their prey. Recently dihydromurexine was found in some molluscs (Roseghini, 1971).
Acetylcholine. An Approach to the Molecular Mechanism of Action by M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview