Download PDF by Francesco Collamati: An Intraoperative Beta−Probe for Cancer Surgery

By Francesco Collamati

ISBN-10: 3319336983

ISBN-13: 9783319336985

ISBN-10: 3319336991

ISBN-13: 9783319336992

This thesis makes a speciality of a unique radio-guided surgical procedure approach for entire tumor resections. It describes all features of the intraoperative probe, in addition to trying out and simulation of the unconventional method. The presentation develops the method from the preliminary thought to real looking feasibility reviews which were the topic of an announcement of the yank Society of Nuclear drugs. only a 12 months after finishing this paintings, the strategy has now been established for the 1st time on a meningioma sufferer, confirming all the predictions made during this thesis.

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Extra resources for An Intraoperative Beta−Probe for Cancer Surgery

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Production of bremsstrahlung by electrons and of Moller/Bhabha secondary electrons is simulated explicitly above thresholds set on a material basis with option EMFCUT. 2 Geometry in FLUKA FLUKA is able to manage very complex geometries via an improved version of the Combinatorial Geometry package. There are two fundamental concepts in CG: bodies and regions. 2 Geometry in FLUKA 23 Originally, bodies were defined as convex solid bodies (finite portions of space completely delimited by surfaces).

The measured attenuation length is therefore shorter than the true one. In order to account for this effect, a devoted simulation with FLUKA was used, as described in Sect. 4. Detectors of several thicknesses were exposed to the Sr source assuming λ = 5 mm and executing the same analysis done on data. 5 mm. From this observation we introduced a geometrical correction factor to translate the measured light yield LYm (T ) into the true one: LYt (T ) = LYm (T ) expT /Tgeom , and estimated Tgeom = 45 mm.

On the other hand, coming to the detector radius, this study leads to a result that is at the same time intuitive and non-trivial: the best radius is the one comparable with the one of the “residual” to be detected (3 mm in this case). Despite being a comprehensible indication, it is a quiet tricky one in the context of a probe for Radio Guided Surgery, in which the size of the object to detect is not known a-priori, and there is instead great variability in it. This study then enforces the idea to develop a “multi-probe system”, composed by for example two different probes: a larger one to detect wider tumors, and a smaller one to detect residuals.

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An Intraoperative Beta−Probe for Cancer Surgery by Francesco Collamati

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