By Alex S. Evers, Mervyn Maze, Evan D. Kharasch (editors)
In recent times our knowing of molecular mechanisms of drug motion and interindividual variability in drug reaction has grown vastly. in the meantime, the perform of anesthesiology has extended to the preoperative setting and various destinations outdoor the OR. Anesthetic Pharmacology: simple rules and scientific perform, moment variation, is an exceptional healing source in anesthesia and significant care: part 1 introduces the foundations of drug motion, part 2 provides the molecular, mobile and built-in body structure of the objective organ/functional approach and part three studies the pharmacology and toxicology of anesthetic medications. the recent part four, Therapeutics of scientific perform, offers built-in and comparative pharmacology and the sensible program of gear in day-by-day scientific perform. Edited via 3 hugely acclaimed educational anesthetic pharmacologists, with contributions from a global staff of specialists, and illustrated in complete color, it is a subtle, ordinary source for all practitioners delivering care within the perioperative interval.
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Additional info for Anesthetic Pharmacology: Basic Principles and Clincial Practice, Second edition
A single drug may be characterized by different potencies for multiple actions, including ED50 for therapeutic action, TD50 for toxicity, and LD50 for lethality. Therapeutics, 11th edn. New York, NY: McGraw Hill, 2006: 1–40. 2. Bourne H, von Zastrow M. Drug receptors and pharmacodynamics. , Basic and Clinical Pharmacology, 10th edn. New York, NY: McGraw Hill, 2007: 11–33. 3. Nyholm TK, Ozdirekcan S, Killian JA. 13 on Thu Jul 21 07:40:08 BST 2011. 002 Cambridge Books Online © Cambridge University Press, 2011 Section 1: Principles of drug action sense the lipid environment.
Signaling regulation is an area of very active research, and a variety of molecular systems involved in this process have been identified. In addition to those mentioned above, these include systems that affect ligand binding specificity and affinity, and coupling between receptors, G proteins, and effectors . 3. Receptor desensitization. A multitude or systems regulates GPCR signaling. , at the levels of gene transcription as well as translation, post-translational modification, and trafficking to the membrane.
Yet further desensitization of the system can occur because of changes in feedback from other cells in the network, which functionally counteract the opiate effect. All of these desensitizing actions are in principle amenable to modulation by drugs. An area of particular interest is the synaptic plasticity induced by opiates, which in essence makes the nervous system “learn” to be less responsive to the drugs. This process, which occurs after both short-term and long-term opiate administration, is highly dependent on changes in glutamate receptor expression, and therefore opiate tolerance can be modulated significantly by drugs that affect glutamate signaling.
Anesthetic Pharmacology: Basic Principles and Clincial Practice, Second edition by Alex S. Evers, Mervyn Maze, Evan D. Kharasch (editors)