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Extra resources for Antibiotics
The investigators focus on resistance to the aminoglycoside amikacin mediated by the aminoglycoside 6'-Nacetyltransferase AAC(6')-Ib, which can also modify several other aminoglycoside antibiotics. The long term goal of this research project is to develop the use of antisense oligonucleotides as tools to selectively inhibit the expression of aac(6')-Ib and other related genes. The specific aims for this grant proposal are: 1a) Identification of synthetic oligonucleotides and analogs that promote cleavage of aac(6')-Ib mRNA by RNase H or RNase P.
Generate_Screen • Project Title: ENZYMATIC BIOSYNTHESIS RXN. ; Biological Chem & Molecular Pharm; Harvard University (Medical School) Medical School Campus Boston, Ma 02115 Timing: Fiscal Year 2003; Project Start 01-JAN-2003; Project End 31-DEC-2005 Summary: (provided by applicant): The emergence of antibiotic-resistant bacteria has become a critical health concern; hence, the design of new agents which will combat the problem of developing resistance to antibiotics is of major interest. The antibiotic novobiocin is produced by Streptomyces spheroides and is a part of the aminocoumarin family of antibiotics whose mode of action is the inhibition of the type II DNA topoisomerase DNA gyrase.
It is anticipated that these studies will advance the development of biosynthetic combinatorial libraries of sugar-modified novobiocin analogs. ; Professor; Biochemistry; Vanderbilt University 3319 West End Ave. Nashville, Tn 372036917 Timing: Fiscal Year 2001; Project Start 01-FEB-1998; Project End 31-JAN-2003 Summary: Five decades ago the introduction modern antibiotics began a revolution in effective therapy for infectious diseases. Today those advances in chemotherapy are in jeopardy due to the increasingly common appearance of drug resistant strains of microorganisms.
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