By Edited by, Jean-Charles Sanchez, Garry L. Corthals, Denis F. Hochstrasser
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Extra resources for Biomedical Application of Proteomics
Fourtanier, G. Dig. Dis. 2002, 20(3/4), 257–265. Reymond, M. , Lippert, H. Proteomics 2003 (in press). -C. Sanchez, G. L. Corthals, D. F. Hochstrasser Copyright © 2004 Wiley-VCH Verlag GmbH & Co. 1 Introduction Cancer chemotherapy relies on the expectation that anticancer drugs will preferentially kill rapidly dividing tumor cells, rather than normal cells. Since a large proportion of the tumor cells have to be killed in order to obtain and maintain a complete remission, large doses of drugs are typically used, with significant toxicity towards proliferating non-malignant cells.
Membrane proteins on tumoral ECs, if present in sufficient abundance and if specific enough, are likely to be ideal targets for diagnostic or therapeutic intervention because of their accessibility from the bloodstream. The following section of this review focuses on the proteomic technologies available to study differentially expressed membrane proteins on ECs. In vitro and in vivo model systems are presented, which have been applied for the investigation of tumoral and normal vasculature. 3 Technologies for the Quantitation of Membrane Proteins in Different Cell Types Membrane proteins are either situated at the interface between the cell and the surrounding environment or at the interface of subcellular compartments, and perform key functions such as cell-to-cell recognition and transport of ions and solutes, as well as acting as receptors for forwarding the diverse signals that reach the cell or subcellular compartment.
The first applications, in particular in the diagnostic market, are emerging: these may well change the fate of thousands of patients, for example by allowing cancer diagnosis in early stages, when these cancers can still be cured. Approaches combining the analysis of complex serum protein patterns with advanced bioinformatics have been shown to detect ovarian, prostate, breast, pancreatic, and bladder cancer with outstanding accuracy, and are paving the way for population screening. It appears that, over the last 10 years, proteomics has matured from a collection of tools to a novel science.
Biomedical Application of Proteomics by Edited by, Jean-Charles Sanchez, Garry L. Corthals, Denis F. Hochstrasser