By Kinam Park (auth.), D. Robert Lu PhD, Svein Øie PhD (eds.)
ISBN-10: 1592597459
ISBN-13: 9781592597451
ISBN-10: 1617374555
ISBN-13: 9781617374555
Research on mobile drug layout and the advance of pharmaceutical structures for the managed supply of a drug to its mobile websites of motion has dramatically advanced lately. In mobile Drug supply: rules and perform, proven investigators in pharmaceutical study and evaluation and summarize the rising rules and perform of mobile drug supply. at the rules part, the authors talk about the huge spectrum of mobile supply, starting from assurance of cell-mediated immunity, gene supply, and protein focusing on, to mobile drug shipping, mobile drug permeability, and quite a few provider structures regarding specified drug supply. at the perform part, the authors specialize in technological advancements in mobile drug supply, together with novel formulations for the supply of DNA and antisense oligonucleotides, in addition to drug focusing on with immunoglobulin formulations and antibody-mediated ways. extra chapters evaluation the elemental suggestions and synthesize our optimum knowing of mobile constitution, shipping, development, and safeguard reaction, and their roles in mobile drug delivery.
entire and updated, mobile Drug supply: rules and perform deals pharmaceutical scientists a uniquely priceless reference source dedicated to illuminating the basics, rules, and perform of mobile drug supply today.
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Extra info for Cellular Drug Delivery: Principles and Practice
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Nature 2000;7:255–262. 23. Matsumoto A, Naito M, Itakura H, et al. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc Natl Acad Sci USA 1990;87:9133–9137. 24. Torchilin VP. TAT peptide-modified liposomes for intracellular delivery of drugs and DNA. Cell Mol Biol Lett 2002;7(2):265–267. 25. Fawell S, Seery J, Daikh Y, et al. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 1994;91:664–648. 26. Wolfe S.
Innate Immune System Innate immunity consists primarily of a chemical response system, including complement, endocytosis, and phagocytosis. Macrophages, for example, detect and engulf extracellular molecules and materials, clearing the system of both debris and pathogens. The innate immune responses in vertebrates are also required to activate adaptive immune responses. Innate immune responses rely on the body’s ability to recognize conserved features of pathogens that are not considered as self, because the pathogen surface contains various classes of common pathogen-associated immunostimulants, such as many types of molecules on microbial surfaces and the double-stranded RNA of some viruses (1,2).
HSV-1 infection starts in epithelial cells, causing a cold sore, and spreads to sensory neurons, whose axons innervate the lips. The initial infection is cleared by immune responses but HSV-1 then becomes latent in these neurons. In this latent state, HSV-1 does not replicate or synthesize protein and, therefore, exists in infected cells with low antigen density that is insufficient to trigger a cell-mediated response. In From: Cellular Drug Delivery: Principles and Practice Edited by: D. R. Lu and S.
Cellular Drug Delivery: Principles and Practice by Kinam Park (auth.), D. Robert Lu PhD, Svein Øie PhD (eds.)
by Robert
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