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Extra info for Chiral Separations Liquid Chromatography

Example text

Mannschreck et al. [67] found that in general the capacity factors of the solutes investigated increased when methanol, ethanol, or propanol, respectively, was used as the eluent. Similar results were found by Rizzi [68] and also by Isaksson et al. [69]. Thus, since the degree to which CTA will swell depends on the kind of solvent used, care must be taken when changing from one solvent to another. If shrinkage of the packing bed occurs, a void volume is created on top of the column, resulting in decreased column efficiency.

Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. FIGURE 12 Chromatograms of enantiomeric resolution of nebivolol on amylose carbamate CSPs. (a)–(c) Chiralpak AD with (a) ethanol, (b) 1-propanol, and (c) 2-propanol. (d, e) Chiralpak AD-RH with (d) ethanol and (e) 1-propanol, separately, as the mobile phase. (From Ref. ) cellulose phenylcarbamate derivatives with ortho substituents have poor chiral resolving power. The superiority of 5-chloro-2-methylphenylcarbamate over the corresponding dimethyl and dichlorophenylcarbamate derivatives of amylose was demonstrated.

Again, the different stereoconfigurations of the enantiomers are responsible for the differences in fit on the chiral selectors. These temporary complexes are stabilized by a number of interactions. The most important interactions are hydrogen, p–p, dipole–induced dipole, ionic, inclusion complexations, and steric interactions. However, the other weaker forces such as van der Waals and charge transfer, also play a crucial role in chiral recognition mechanisms. The chiral recognition mechanism on chiral ligand exchange selectors is different from that on the other selectors.

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