By John E. Kay (auth.), Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (eds.)
ISBN-10: 9400908598
ISBN-13: 9789400908598
ISBN-10: 9401068747
ISBN-13: 9789401068741
Cyclosporin has had a outstanding influence on scientific organ transplantation. ahead of its creation, massive advances have been made within the grafting of significant organs, relatively the kidney, center and liver. in lots of constructed nations, besides the fact that, transplantation used to be no longer thought of wo-rthwhile by way of achieve for the funding of assets. the enhanced result of kidney grafts following using cyclosporin has replaced this perspective. for all sorts of organ transplantation, cyclosporin has ended in an development of practical graft survival and has allowed a discount in steroid dose and, every now and then, no steroids in any respect. It has authorized the 1st winning experimental transplantation of the center and lungs in primate species via Reitz and associates and their effects have been utilized on to the medical institution. It was once mostly as a result advent of cyclosporin that the Washington Consensus assembly on Liver Transplantation got here to a beneficial advice and the end result has been the proliferation of devices appearing liver transplantation, nearly fifty in North the United States and one other fifty in Europe, the place formerly there have been a handful. Having been fascinated by cyclosporin for organ grafting from the start, i've been capable of witness those advancements that have a long way surpassed my expectancies as soon as the nephrotoxicity of cyclosporin used to be verified in guy. it really is becoming that Dr.
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Additional resources for Cyclosporin: Mode of Action and Clinical Applications
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Ciclosponn in Autoimmwle Diseases. (Berlin: Springer-Verlag). pp. 24-32 22. Weissm. A. and Imboden. J. (1987) Cell surface molecules and early events in T lymphocyte activation. Adv. Immrmol .. 41. 1 23. Hodgkin. P. D .. Hape!. A. ).. Johnson. R. M .. Young. I. G. and Lafferty. K. J. (1987) 32 CsA MODULATION OF THE IL-2fIL-2 RECEPTOR PATHWAY 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. Blocking of the delivery of the antigen-mediated Signal to the nucleus of T cells by Cyclosporine. Transplmlla/ioll.
Acad. Sci. USA, 83, 2599-2603 89. DanieL T. C and Ives. H. E. (1987) Cyclosporin A inhibits kinase C-independent activation of the Na + /:-r+ exchange by platelet-derived growth factor and vanadate. Biochem. Biophys. Res. Commun .. 145, llI-1I7 90. Slater. L. M .. Sweet, P.. Stupecky, M. and Gupta, S. (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukaemia in uirro. ]. C/in. • 77. 1405-1408 91. NicchiUa. C. V.. Kamoun, M. and Williamson. J. R. (1985) Cyclosporine augments receptormediated cellular Ca2 + fluxes in isolated hepatocytes.
A and PermmongkoL C. (1986) Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. Proc. Natl. Acad. Sci. USA, 83, 2599-2603 89. DanieL T. C and Ives. H. E. (1987) Cyclosporin A inhibits kinase C-independent activation of the Na + /:-r+ exchange by platelet-derived growth factor and vanadate. Biochem. Biophys. Res. Commun .. 145, llI-1I7 90. Slater. L. M .. Sweet, P.. Stupecky, M. and Gupta, S. (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukaemia in uirro.
Cyclosporin: Mode of Action and Clinical Applications by John E. Kay (auth.), Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (eds.)
by William
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