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The Repressor The last aspect of the model we shall discuss here is concerned with the nature of the repressor and its interaction with specific metabolites. From the previously reported observations, it has been concluded that the repressor— which is defined as the product of the regulator gene, able to exhibit differ­ ent properties as a result of mutations affecting the regulator gene—acts on the corresponding operator to prevent synthesis of the messengers by the whole operon. In addition, the repressor is able to interact with specific metabolites which can either activate it (repression) or inactivate it (induc­ tion).

Inhibits protein synthesis, since the active system (R ) prevents protein synthesis while the inactive system (R~) allows protein synthesis at maximal rate. , 1961) and in phage (Sussman and Jacob, 1962): at low temperature, the repression is active and the systems operate under the same + conditions as in the wild type (R ). At high temperature, the repression systems are inactivated, an effect which results in a constitutive synthesis of /3-galactosidase or in the production of phage. This type of mutation has rather dramatic consequences in phage.

AND M A L I N G , B . D . ( 1 9 6 1 ) . T h e the composition mutations, of t h e t r y p t o p h a n effects a n d p r o p e r t i e s of t h e A p r o t e i n of Escherichia synthetase. Cold Spring Harbor Symposia Quant. Biol. 2 6 , 1 1 - 2 3 . of 14, 311- mutation on coli t r y p t o p h a n Genetic Repression, Allosteric Inhibition, and Cellular Differentiation F R A N C O I S J A C O B AND J A C Q U E S M O N O D Services de Genetique microbienne et de Biochimie cellulaire, Institut Pasteur, Paris Introduction It is generally recognized today that the characteristics of an individual, its development and functioning, are written in a codescript along its chromo­ somes.

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