By Edward J. Cragoe, Jr. (Eds.)
ISBN-10: 0841204640
ISBN-13: 9780841204645
ISBN-10: 0841205752
ISBN-13: 9780841205758
content material: Prostaglandins and renal functionality : implications for the job of diuretic brokers / J.C. McGiff and P.Y-K Wong --
Structure-activity relationships of aminobenzoic acid diuretics and similar compounds / O.B. Tvaermose Nielsen and P.W. Feit --
4-(3-sulfamoylphenyl)thiazolidin-4-ols : a singular type of sulfonamide compounds with salidiuretic job / H.-J. Lang, B. Knabe, R. Muschaweck, M. Hropot, and E. Lindner --
Sulfonamide diuretics / L.H. Werner, E. Habicht, and J. Zergenyi --
Diuretic and uricosuric houses of tienilic acid (ticrynafen) in mice, rats, and anesthetized beagle canine : antihypertensive task in SH rats and structure-activity courting / P. Bessin, J. Bonnet, M.F. Malin, C. Jacquemin, N. De Breze, I. Pelas, L. Desgroux, B. Agier, and M. Dutarte --
Ticrynafen : an antihypertensive, diuretic, uricosuric agent / A.R. Maass, I.B. Snow, R. Erickson, and R.M. Stote --
2-aminomethylphenols : a brand new classification of saluretic brokers / R.L. Smith, E.M. Schultz, G.E. Stokker, and E.J. Cragoe, Jr. --
1-aralkyl-2-pyrazolin-5-ones : a brand new category of hugely effective diuretics with excessive ceiling job / H. Horstmann, E. Möller, E. Wehinger, and ok. Meng --
Quincarbate : a consultant of a brand new category of diuretics with 1,4-dioxino[2,3-g]quinolone constitution / Th. A.C. Boschman, J. Van Dijk, J. Hartog, and J.N. Walop --
Etozolin : a singular diuretic / G. Satzinger, M. Herrmann, K.-O. Vollmer, A. Merzweiler, H. Gomahr, O. Heidenreich, and J. Greven --
The evolution of the (aryloxy)acetic acid diuretics / O.W. Woltersdorf, Jr., S.J. De Solms, and E.J. Cragoe, Jr.
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Sample text
This type of diuretic response may be desirable in the treatment of hypertension. Unfortunately, none of the compounds described were potassium-sparing nor did they have appreciably less effect on glucose tolerance; however, no uricosuric effect was observed. This brief overview of some of our work on sulfonamide diuretics illustrates one of the problems we encounter in medicinal chem i s t r y ; namely, that encouraging biological data in animals do not always translate into equally favorable c l i n i c a l results.
Med. Chem. (1970), 13, 1071. 3. F e i t , P. , J. Med. Chem. (1971), 14, 432. 4. F e i t , P. W. and Nielsen, O. B. , J. Med. Chem. (1972), 15, 79. 5. F e i t , P. , Nielsen, O. Β. T. , J. Med. Chem. (1973), 16, 127. 6. Nielsen, O. B. , Nielsen, C. K. and F e i t , P. , J. Med. Chem. (1973), 16, 7. F e i t , P. , Nielsen Chem. (1974), 17, 572. 8. Nielsen, O. B. , Bruun, H . , Bretting, C. and F e i t , P. , J. Med. Chem. (1975), 18, 41. 9. F e i t , P. W. and Nielsen, O. B. , J. Med. Chem. (1976), 19, 402.
Figure 4. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1978. 33 DIURETIC AGENTS 34 ι 5 Con trol 1 10 1 15 1 20 1 25 1 30 | days Glycyrrhetinic acid Figure 5. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1978. 3. LANG ET A L . 4-(3-Sulfamoylphenyl)thiazolindin-4-oh Π 4 2 35 Ά 5 1 MOI 1251 1501 l10l Dose, mg/kg Figure 6. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1978. 36 DIURETIC AGENTS concentrations have also been performed. 5, 8 and 25 mg/kg of Hoe 740 were not influenced; however, these levels were decreased in normal rats during the same length of treatment after oral administration of Hoe 740 at 4, 40 and 400 mg/kg.
Diuretic Agents by Edward J. Cragoe, Jr. (Eds.)
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